NFL Week 5 DFS: Matchups, Slates & Lineup Strategy

By the FantasySportsEdge TeamA small team of data and AI engineers who play DFSUpdated October 2, 2026

Week 5 is the first week with teams on bye. Carolina and Kansas City are off, so the schedule has 15 games instead of 16. Tampa Bay at Dallas opens the week Thursday night.

Philadelphia at Jacksonville kicks off at 9:30 AM ET in London, ahead of the rest of the Sunday slate. The other 13 Sunday and Monday games run in the usual windows.

Full Week 5 schedule

MatchupDateKickoffDFS window
Tampa Bay Buccaneers at Dallas CowboysThursday, October 88:15 PM ETThursday Night — Thursday Night Football
Philadelphia Eagles at Jacksonville JaguarsSunday, October 119:30 AM ETSpecial — London, England. International game
Chicago Bears at Green Bay PackersSunday, October 111:00 PM ETEarly window
Cincinnati Bengals at Miami DolphinsSunday, October 111:00 PM ETEarly window
Cleveland Browns at New York JetsSunday, October 111:00 PM ETEarly window
Houston Texans at Tennessee TitansSunday, October 111:00 PM ETEarly window
Indianapolis Colts at Pittsburgh SteelersSunday, October 111:00 PM ETEarly window
Las Vegas Raiders at New England PatriotsSunday, October 111:00 PM ETEarly window
Minnesota Vikings at New Orleans SaintsSunday, October 111:00 PM ETEarly window
New York Giants at Washington CommandersSunday, October 111:00 PM ETEarly window
Denver Broncos at Los Angeles ChargersSunday, October 114:05 PM ETLate afternoon
Detroit Lions at Arizona CardinalsSunday, October 114:25 PM ETLate afternoon
San Francisco 49ers at Seattle SeahawksSunday, October 114:25 PM ETLate afternoon
Baltimore Ravens at Atlanta FalconsSunday, October 118:20 PM ETSunday Night — Sunday Night Football
Buffalo Bills at Los Angeles RamsMonday, October 128:15 PM ETMonday Night — Monday Night Football

How the Week 5 slates break down

Teams on bye

Carolina and Kansas City are off this week. Their players score nothing, so check every saved lineup for anyone from those two teams before you submit.

Early slate: eight games, 1:00 PM ET

Chicago at Green Bay, Cincinnati at Miami, Cleveland at the Jets, Houston at Tennessee, Indianapolis at Pittsburgh, Las Vegas at New England, Minnesota at New Orleans, and the Giants at Washington.

Afternoon slate: three games, 4:05 and 4:25 PM ET

Denver at the Chargers kicks at 4:05 PM ET. Detroit at Arizona and San Francisco at Seattle kick at 4:25 PM ET.

Primetime, showdown, and the international game

Tampa Bay at Dallas opens the week Thursday night at 8:15 PM ET. Philadelphia at Jacksonville is the 9:30 AM ET London kickoff. Baltimore at Atlanta closes Sunday on Sunday Night Football at 8:20 PM ET, and Buffalo at the Rams play Monday Night Football at 8:15 PM ET.

Lineup strategy for Week 5

Two teams are off, so the pool is smaller

The main slate has 11 games, down from 12 in Week 4. Fewer games means fewer places to find a stack, and the same popular games get picked more often. Look for a game that fits your build but gets less attention.

The London game is its own slate

Philadelphia at Jacksonville kicks off at 9:30 AM ET, hours before the 1:00 PM games. Sites usually run a game like this as a separate slate, so check each site's slate list before you build. A two-team pool is a different job from a main-slate build.

Four games of usage data is a real sample

By Week 5, a player's snap share and target share have been tested against four different opponents. A role that held across all four tells you more than one big box score. Price still lags a role that grew slowly.

Thursday opens the week before the injury news settles

Tampa Bay at Dallas is on Thursday, so you set that lineup days before the Sunday reports are final. If you play the Thursday-to-Monday slates, check each player's status again before the Sunday games start.

Build your Week 5 lineup

Take these matchups into the NFL lineup builder to lock in players and build for DraftKings or FanDuel, check this week's projections before you lock anyone in, and scan the injury report for status changes that land after this page publishes.

Common Week 5 DFS questions

What's the Week 5 NFL DFS schedule?
Fifteen games: Tampa Bay at Dallas on Thursday night, Philadelphia at Jacksonville at 9:30 AM ET in London, eight games at 1:00 PM ET, three in the 4:05-4:25 PM ET window, Baltimore at Atlanta on Sunday Night, and Buffalo at the Rams on Monday Night.
Which teams have a bye in Week 5?
Carolina and Kansas City. Fifteen games are on the schedule instead of 16.
How many games are on the Week 5 main slate?
Eleven: the eight 1:00 PM ET games and the three games in the 4:05-4:25 PM ET window. The London game, Thursday night, Sunday night, and Monday night each run separately.
What time is Week 5 Thursday Night Football?
Tampa Bay at Dallas kicks off at 8:15 PM ET on Thursday, October 8.

More weeks

Matchup dates and kickoff times checked against the league schedule on October 2, 2026 and can move if the league makes a schedule change. See our methodology for how these pages and our projections get built, and the NFL DFS hub for other weeks.